VIRAL ETIOLOGIES OF CHRONIC DERMATOLOGIC INFECTIONS: A CLINICAL INVESTIGATION

Abstract

This clinical trial explored the viral etiologies of chronic dermatologic infections using the quantitative viral load profiling, lesion-duration analytics, and severity-score modelling on a heterogeneous patient cohort.  The review of nine large clinical samples revealed a steady high viral load - ranging between moderate (1,500 copies/mL) and very high (>50,000 copies/mL) - in patients that had persistent lesions, which showed a strong positive correlation between the intensity of viral loads and the duration of lesions.  The results showed that patients who had high viral replication index showed a significantly greater chronicity and clinical severity score of their lesions, indicating that viral persistence is one of the main factors affecting the course of the disease.  These findings were also supported by twelve higher graphical models.  The line-trend analysis demonstrated that the virus activity persisted following the acute phase and hybrid bar-line graphs indicated the influence of viral replication on the increment of symptoms with time.  The results of scatter and composite correlation showed that the groups of patients with high severity were significantly clustered with both prolonged duration of the lesion and high viral load.  The use of pie-distribution modelling revealed that not all viral subtypes had an equal contribution, with some of them being more prevalent in chronic patients.